1,197 research outputs found

    Evolution of shuttle avionics redundancy management/fault tolerance

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    The challenge of providing redundancy management (RM) and fault tolerance to meet the Shuttle Program requirements of fail operational/fail safe for the avionics systems was complicated by the critical program constraints of weight, cost, and schedule. The basic and sometimes false effectivity of less than pure RM designs is addressed. Evolution of the multiple input selection filter (the heart of the RM function) is discussed with emphasis on the subtle interactions of the flight control system that were found to be potentially catastrophic. Several other general RM development problems are discussed, with particular emphasis on the inertial measurement unit RM, indicative of the complexity of managing that three string system and its critical interfaces with the guidance and control systems

    A rapid graphical technique for obtaining radar data time history for close earth orbits

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    Radar tracking parameters and contact time errors from graphic estimation of radar tracking coverage of near earth orbit

    Does International Trump Domestic Trade? The Seed Potato Market in Canada

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    trade, potato, Agricultural and Food Policy, International Development,

    Does International Trump Domestic Trade? The Seed Potato Market in Canada

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    trade, potato, Canada, Agricultural and Food Policy, International Development, International Relations/Trade,

    Disease Outbreaks and Agricultural Trade: The Case of Potatoes

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    This study analyzed the impact of PVYn and potato wart disease outbreaks in PEI on the potato industry. These disease outbreaks resulted in the loss of the US seed export market to PEI producers. The effects of the disease outbreaks were mitigated through value-added processing. Price premiums for processed potatoes allowed PEI potato producers to abandon seed exports without incurring losses. Evidence is presented to suggest that other countries have also used this approach when export restrictions were placed on domestic agricultural industries. Policy response to the two disease outbreaks include: i) development of a zones policy that helped to reopen markets into the US; and ii) financial compensation to producers above the minimum levels required under the Seeds Act and Regulations. Implementation of the zones policy had beneficial impacts on the potato industry and is mirrored in other disease outbreaks. In contrast, compensation above minimum requirements may set a costly precedent for future disease outbreaks and may have caused moral hazard problems.disease, trade, potatoes, Canada, food, safety, Agricultural and Food Policy, International Development, International Relations/Trade,

    A Millimeter-Wave Achromatic Half Wave Plate

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    We have constructed an achromatic half wave plate (AHWP) suitable for the millimeter wavelength band. The AHWP was made from a stack of three sapphire a-cut birefringent plates with the optical axes of the middle plate rotated by 50.5 degrees with respect to the aligned axes of the other plates. The measured modulation efficiency of the AHWP at 110 GHz was 96±1.596 \pm 1.5%. In contrast, the modulation efficiency of a single sapphire plate of the same thickness was 43±443 \pm 4%. Both results are in close agreement with theoretical predictions. The modulation efficiency of the AHWP was constant as a function of incidence angles between 0 and 15 degrees. We discuss design parameters of an AHWP in the context of astrophysical broad band polarimetry at the millimeter wavelength band.Comment: In print - Applied Optics, 14 pages, 7 figure

    Tweda Users Manual

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    1 online resource (PDF, 17 pages

    Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences

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    <p>Abstract</p> <p>Background</p> <p>Precise and efficient methods for gene targeting are critical for detailed functional analysis of genomes and regulatory networks and for potentially improving the efficacy and safety of gene therapies. Oligomerized Pool ENgineering (OPEN) is a recently developed method for engineering C2H2 zinc finger proteins (ZFPs) designed to bind specific DNA sequences with high affinity and specificity <it>in vivo</it>. Because generation of ZFPs using OPEN requires considerable effort, a computational method for identifying the sites in any given gene that are most likely to be successfully targeted by this method is desirable.</p> <p>Results</p> <p>Analysis of the base composition of experimentally validated ZFP target sites identified important constraints on the DNA sequence space that can be effectively targeted using OPEN. Using alternate encodings to represent ZFP target sites, we implemented Naïve Bayes and Support Vector Machine classifiers capable of distinguishing "active" targets, i.e., ZFP binding sites that can be targeted with a high rate of success, from those that are "inactive" or poor targets for ZFPs generated using current OPEN technologies. When evaluated using leave-one-out cross-validation on a dataset of 135 experimentally validated ZFP target sites, the best Naïve Bayes classifier, designated ZiFOpT, achieved overall accuracy of 87% and specificity<sup>+ </sup>of 90%, with an ROC AUC of 0.89. When challenged with a completely independent test set of 140 newly validated ZFP target sites, ZiFOpT performance was comparable in terms of overall accuracy (88%) and specificity<sup>+ </sup>(92%), but with reduced ROC AUC (0.77). Users can rank potentially active ZFP target sites using a confidence score derived from the posterior probability returned by ZiFOpT.</p> <p>Conclusion</p> <p>ZiFOpT, a machine learning classifier trained to identify DNA sequences amenable for targeting by OPEN-generated zinc finger arrays, can guide users to target sites that are most likely to function successfully <it>in vivo</it>, substantially reducing the experimental effort required. ZiFOpT is freely available and incorporated in the Zinc Finger Targeter web server (<url>http://bindr.gdcb.iastate.edu/ZiFiT</url>).</p
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